Structure Of 6 Mercaptopurine

MedChem Express IC50 Value. A second independent x-ray diffraction determination.

Mercaptopurine An Overview Sciencedirect Topics

The crystal and molecular structure of 6-mercaptopurine monohydrate.

Structure of 6 mercaptopurine. The characteristic reflection was found at 2θ 723 attributed to the 011 peak of ZIF-8. An antitumor drug 6-mercaptopurine monohydrate has a low oral bioavailability about 16 due to its poor aqueous solubility. Authors E Sletten J Sletten L H Jensen.

KEY WORDS molecular docking human serum albumin 6-Mercaptopurine. Let us know if you have any questions regarding this information. Dear email protected Your doctor has discussed the following medication with you.

6-MP is an immunosuppressive drug. The catabolism of mercaptopurine and its metabolites is complex. This medication belongs to a class of drugs called immunomodulators.

It is found that 6-Mercaptopurine hydrate leads to a dose-dependent increase in NR4A3 protein levels. This indicated that the crystallinity of ZIF-8 was not altered by the. Oral tablets are pale yellow to buff.

Both AZ and 6-MP dose-dependently suppressed PBMC blastogenesis. Structure for Mercaptopurine DB01033. 001 in a dose-responsive manner.

6-MERCAPTOPURINE 6-MP Modified. A second independent x-ray diffraction determination. The geometries of ten configurations were optimized with full freedom.

The substitution of a variety of other groups eg alkyl halogen cyano and carboxy for the mercapto group led in general to less active or inactive compounds. In this work the density functional theory B3LYP has been used to investigate the structures and properties of the configurations between 6-mercaptopurine 6MP and Ag 8 clusters using 6-311G level as well as an effective pseudo potential LANL2DZ. In this work the effect on the electronic structure of an additional anchor to the SAu bond using 6 mercaptopurine as a model system has been investigated.

The crystal and molecular structure of 6-mercaptopurine monohydrate. 1 include methylation of SH group by thiopurine-S-methyltrans-ferase TPMT and oxidation by the enzyme xanthine oxidase XO 5. Heterocyclic analogs of 6-mercaptopurine such as azathioprine were invented to shield it from metabolic effects 67.

6-mercaptopurine central pathways of deactivation Fig. 6-MP treatment increases cell surface GLUT4 in both basal cells 18- to 36-fold P 001 and insulin-stimulated cells 29- to 44-fold P 001. Crystal structures of the bovine enzyme in complex with the physiological substrate hypoxanthine at 18 A resolution and the chemotherapeutic agent 6-mercaptopurine at 26 A resolution have been determined showing in each case two alternate orientations of substrate in the two active sites of the crystallographic asymmetric unit.

6-Mercaptopurine hydrate 6-MP induces NR4A3 transcriptional activity 16- to 11-fold P. 6-Mercaptopurine monohydrate C5H6N4OS CID 2724350 - structure chemical names physical and chemical properties classification patents literature biological activities safetyhazardstoxicity information supplier lists and more. The crystal and molecular structure of 6-mercaptopurine monohydrate Acta Crystallogr B.

In humans after oral administration of 35 S-6-mercaptopurine urine contains intact mercaptopurine thiouric acid formed by direct oxidation by xanthine oxidase probably via 6-mercapto-8-hydroxypurine and a number of 6-methylated thiopurines. Chemically the 6-mercaptopurine scaffold can also be modulated by an appropriate selection of the substituents that can be located at C-2 N-1 C-6 N-3 C-8 N-7 and N-9 posi-. 6-Mercaptopurine is a water insoluble purine analogue which attracted attention due to its antitumor and immunosuppressive properties.

Studies with Lactobacillus casei 14 23 30 revealed certain structure-activity relationships which formed the basis for further syntheses and for the examination of these compounds against neoplastic growth. It was found that in case of neutral form of 6-MP the binding force was mainly hydrophobic interaction while the electrostatic interaction and hydrogen bond were involved in the binding process of anionic form of 6-MP. MOL SDF 3D-SDF PDB SMILES InChI.

The electronic structure of aromatic and aliphatic thiols on Au111 has been extensively studied in relation to possible applications in molecular electronics. These types of heterocycles take part of the core structure of guanine and adenine in nucleic acids DNA and RNA being involved in diverse in vivo catabolic and anabolic metabolic pathways. 14951249 nM PBMC blastogenesis 1.

The finding that 6-mercaptopurine 6-MP is inhibitory to Sarcoma 180 8 and produces a high percentage. The powder XRD pattern showed no significant change in the crystalline structure of 6 email protected with respect to the plain ZIF-8. Mercaptopurine is a yellow crystalline powder that decomposes at 313314 C.

Here is some additional information. Some peaks could not be indexed and are represented as unknown phase. Mercaptopurine differs from purine by having a sulfhydryl instead of a hydroxyl group at the 6 position.

The specificity of action of 6-mercaptopurine 6-MP against Sarcoma 180 has been examined through the synthesis and testing of 102 related substances. To improve its solubility two cocrystals of 6-mercaptopurine with 4-. Mercaptopurine also referred to as 6-mercaptopurine or 6-MP is a purine analogue that is effective both as an anticancer and an immunosuppressive agent and is used to treat leukemia and autoimmune diseases as a corticosteroid-sparing agent.

Two cocrystals of 6-MP with 4-hydroxybenzoic acid 1 and 24-dihydroxybenzoic acid 2 as well as two salts of 6-MP with piperazine in 11 3 and. The methylthiopurines yield appreciable amounts of. At least two binding sites of 6-MP in HSA structure.

The crystal and molecular structure of 6-mercaptopurine monohydrate. C5 H4 N4 S.

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6 Mercaptopurine Cas 50 44 2 Chemsrc

Apexbio Mercaptopurine 6 Mp Purine Synthesis Inhibitor Cas 50 44 2

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